The Megasporebiotic and Megaprebiotic Microbiome Diversity Study


A new study published in the International Journal of Pharmaceutics demonstrates how this unique probiotic and prebiotic combination enhances microbiome diversity and boosts the production of short chain fatty acids (1).

Taking Megasporebiotic and Megaprebiotic together offers synergistic benefits for microbiome diversity and metabolism.

Bacillus spore probiotics have adapted to live in the intestinal tract. Previous study has supported the ability of spore probiotics to help stimulate immune health, and mitigate leaky gut as measured by reduced absorption of inflammatory toxins (known as metabolic endotoxemia).

Those past findings are detailed in The Megasporebiotic Leaky Gut Study.

Synbiotic formulations are products that combine probiotics with prebiotics. Synbiotics have been previously studied with atopic dermatitis, lipid and blood sugar metabolism, measures of weight balance, and the relief from a range of digestive symptoms.

In new analysis, five Bacillus strains found in Megasporebiotic were also demonstrated to increase levels of Bifidobacteria, Akkermansia muciniphila, and Faecalbacterium prausnitzii in the colon, as well as the beneficial short-chain fatty acids: acetate, propionate, and butyrate (see image below).

When Megaprebiotic was taken with Megaspore, the findings were even more profound…

Megasporebiotic and Megaprebiotic Study Results:

Probiotic and synbiotic treatment chart(Img source:

The combination of Bacillus probiotics found in Megasporebiotic and the unique oligosaccharides in Megaprebiotic increased production of all SCFA’s (acetate, propionate, butyrate) and significantly increased the abundance of Bifidobacterium spp, Lactobacillus spp, Faecalibacterium prasunitzii, and Akkermansia muciniphila to a greater degree than just taking Megasporebiotic by itself.

Taking Megasporebiotic and Megaprebiotic together provides a synbiotic benefit that may profoundly enhance microbiome health and diversity.

  • The enhanced strains are known to be prevalent in healthy guts when compared to unhealthy guts.
  • Short chain fatty acids (SCFAs) help maintain bacterial and mucosal health, as well as serve as fuel for colon cells and the immune system. Healthy bacteria create more SCFAs in return. The healthy production of SCFA’s is also associated with far-reaching metabolic and cardiovascular health benefits (2). While the goal is to supply needs with probiotics, prebiotics, polyphenols, and diet, You can also supplement directly with SCFA’s.
  • This corroborated previous 3rd-party findings when using individual ingredients (oligo-, xylo-, and galactosaccharides) of the MegaPrebiotic prebiotic blend (3, 4, 5)

Because of Megaspore’s previously demonstrated ability to enhance metabolic markers and reduce leaky gut, future studies using Megasporebiotic and Megaprebiotic may reveal synbiotic benefits for a range of metabolic disorders (obesity, diabetes, lipid metabolism, and more).

Get the Latest Updates and Special Offers

Sign up below to be the first to receive latest product updates and special offers only to those on this list!